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En1tm1Gld
Targeted Allele Detail
Nomenclature
Symbol: En1tm1Gld
Name: engrailed 1; targeted mutation 1, Martyn Goulding
MGI ID: MGI:2137030
Synonyms: En1-, En1taulacZ, En1/tauLacZ, En1tau-LacZ, En1tlZ
Gene: En1  Location: Chr1:120602418-120607992 bp, + strand  Genetic Position: Chr1, 52.74 cM, cytoband C2-qter
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:52637
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA tau-lacZ reporter gene cassette was inserted into the first exon, replacing sequences encoding the endogenous methionine initiation codon and the first 72 amino acids. Heterozygous mice expressed tau-beta-galactosidase that was indistinguishable from the endogenous expression pattern of En1. (J:52637)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any En1 Mutation:  8 strains or lines available
Notes
Mice heterozygous for En1tm1Gld and homozygous for En2tm1Alj display Phenotypic Similarity to Human Syndrome: Parkinson Disease (J:115270)

References
Original:  J:52637 Saueressig H, et al., Engrailed-1 and netrin-1 regulate axon pathfinding by association interneurons that project to motor neurons. Development. 1999 Oct;126(19):4201-12
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory