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En1tm1Gld
Targeted Allele Detail
Summary
Symbol: En1tm1Gld
Name: engrailed 1; targeted mutation 1, Martyn Goulding
MGI ID: MGI:2137030
Synonyms: En1-, En1taulacZ, En1/tauLacZ, En1tau-LacZ, En1tlZ
Gene: En1  Location: Chr1:120530246-120535719 bp, + strand  Genetic Position: Chr1, 52.74 cM, cytoband C2-qter
Alliance: En1tm1Gld page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:52637
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA tau-lacZ reporter gene cassette was inserted into the first exon, replacing sequences encoding the endogenous methionine initiation codon and the first 72 amino acids. Heterozygous mice expressed tau-beta-galactosidase that was indistinguishable from the endogenous expression pattern of En1. (J:52637)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any En1 Mutation:  32 strains or lines available
References
Original:  J:52637 Saueressig H, et al., Engrailed-1 and netrin-1 regulate axon pathfinding by association interneurons that project to motor neurons. Development. 1999 Oct;126(19):4201-12
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory