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Targeted Allele Detail
Symbol: Rettm1Cos
Name: ret proto-oncogene; targeted mutation 1, Frank Costantini
MGI ID: MGI:2136894
Synonyms: c-ret-, Ret-, ret-k-
Gene: Ret  Location: Chr6:118128706-118174679 bp, - strand  Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
Germline Transmission:  Earliest citation of germline transmission: J:23852
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced 0.8 kb of sequence, including the codon for an invariant lysine required for kinase activity. Northern blot analysis did not detect normal transcripts in brains of homozygous mice, but did detect several transcripts with sizes consistent with predicted products of the mutant allele. (J:23852)
Generation of the Rettm6.1Vpa and Rettm6.2Vpa alleles
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 45 assay results
In Structures Affected by this Mutation: 17 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ret Mutation:  40 strains or lines available
Original:  J:23852 Schuchardt A, et al., Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret [see comments]. Nature. 1994 Jan 27;367(6461):380-3
All:  57 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.20
The Jackson Laboratory