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Apptm1Dbo
Targeted Allele Detail
Nomenclature
Symbol: Apptm1Dbo
Name: amyloid beta (A4) precursor protein; targeted mutation 1, David R Borchelt
MGI ID: MGI:2136847
Synonyms: App-
Gene: App  Location: Chr16:84954440-85173707 bp, - strand  Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:25512
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any App Mutation:  9 strains or lines available
References
Original:  J:25512 Zheng H, et al., beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell. 1995 May 19;81(4):525-31
All:  60 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory