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Targeted Allele Detail
Symbol: Vhltm1.1Jae
Name: von Hippel-Lindau tumor suppressor; targeted mutation 1.1, Rudolf Jaenisch
MGI ID: MGI:2136646
Synonyms: 1-lox allele, VHL1, Vhld, Vhl
Gene: Vhl  Location: Chr6:113623959-113631633 bp, + strand  Genetic Position: Chr6, 52.81 cM
Vascular tumors in Vhltm1.1Jae/Vhl+ livers and vascular lesions in Vhltm1Jae/Vhltm1Jae Tg(Alb-cre)21Mgn/0 mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:67505
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA CMV-hyTK selection cassette flanked by two loxP sites was inserted approximately 2.6kb upstream of exon 1. A third loxP site was inserted into intron 1. ES cells with this mutation were transiently transfected with a vector driving expression of Cre recombinase. ES cells containing only one loxP site, in which the promoter and exon 1 were deleted, were selected. These cells were injected into blastocyts to generate a the allele designated Vhltm1.1Jae. (J:67505)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vhl Mutation:  5 strains or lines available
Original:  J:67505 Haase VH, et al., Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1583-8
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory