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Gt(ROSA)26Sortm2Sho
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm2Sho
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Stuart Orkin
MGI ID: MGI:2136519
Synonyms: R26floxGFP, R26-GFP, ROSA26-EGFP, ROSA26-EGFTf, ROSA26-flox-STOP-flox-GFP, Rosa26LOXPEGFP, Rosa26R-eGFP, RosaC, ROSA-GFP, ROSA-loxP-stop-loxP-GFP loxP-GFP
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66742
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Conditional ready, Reporter)
Mutation:    Insertion
 
Mutation detailsThese mice contain an Enhanced Green Fluorescent Protein (EGFP) gene inserted into the Gt(ROSA)26Sor locus. Expression of the EGFP gene is blocked by a loxP-flanked STOP fragment placed between the EGFP sequence and the Gt(ROSA)26Sor promoter. This strain serves as a reporter strain, with successful Cre excision being indicated by EGFP expression in Cre-expressing tissues. (J:66742)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 38 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  741 strains or lines available
References
Original:  J:66742 Mao X, et al., Activation of EGFP expression by cre-mediated excision in a new ROSA26 reporter mouse strain. Blood. 2001 Jan 1;97(1):324-6
All:  148 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory