Gt(ROSA)26Sor^tm2Sho
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm2Sho
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Stuart Orkin
• MGI ID: MGI:2136519
• Synonyms: R26floxGFP, R26-GFP, ROSA26-EGFP, ROSA26-EGFT^f, ROSA26-flox-STOP-flox-GFP, Rosa26LOXP^EGFP, Rosa26R-eGFP, Rosa^C, ROSA-GFP, ROSA-loxP-stop-loxP-GFP loxP-GFP
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm2Sho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66742
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: These mice contain an Enhanced Green Fluorescent Protein (EGFP) gene inserted into the Gt(ROSA)26Sor locus. Expression of the EGFP gene is blocked by a loxP-flanked STOP fragment placed between the EGFP sequence and the Gt(ROSA)26Sor promoter. This strain serves as a reporter strain, with successful Cre excision being indicated by EGFP expression in Cre-expressing tissues. (J:66742)

Expression

In Mice Carrying this Mutation:

50 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 942 strains or lines available

References

• Original: J:66742 Mao X, et al., Activation of EGFP expression by cre-mediated excision in a new ROSA26 reporter mouse strain. Blood. 2001 Jan 1;97(1):324-6
• All: 161 reference(s)