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Tg(Tek-cre)12Flv
Transgene Detail
Nomenclature
Symbol: Tg(Tek-cre)12Flv
Name: transgene insertion 12, Richard A Flavell
MGI ID: MGI:2136412
Synonyms: btie2-cre, CreTek, Tek-Cre, Tet-cre, Tie2-Cre, Tie2-Cre, TIE2/cre, TIE2Cre, TIE2Cre+, Tie2(Tek)-Cre
Transgene: Tg(Tek-cre)12Flv  Location: unknown  
Transgene
origin
Strain of Origin:  (C3H x C57BL/6)F2
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsCre recombinase expression is driven by a mouse endothelial-specific receptor tyrosine kinase promoter/enhancer. Recombinase activity is detected in endothelial cells during embryogenesis and adulthood. Expression was also detected in hematopoietic cells. The promoter has also been reported to be active in female germ cells. A low frequency of deletion events are also observed by inheritance from the male germline. (J:68147, J:138838)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tek     Summary of all recombinase alleles driven by Tek.
 

Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 35 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:68147 Koni PA, et al., Conditional Vascular Cell Adhesion Molecule 1 Deletion in Mice. Impaired lymphocyte migration to bone marrow. J Exp Med. 2001 Mar 19;193(6):741-54
All:  194 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory