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Fgfr4tm1Cxd
Targeted Allele Detail
Nomenclature
Symbol: Fgfr4tm1Cxd
Name: fibroblast growth factor receptor 4; targeted mutation 1, Chu-Xia Deng
MGI ID: MGI:2135678
Synonyms: FR4KO
Gene: Fgfr4  Location: Chr13:55152640-55168759 bp, + strand  Genetic Position: Chr13, 29.8 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:50677
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (knock-out)
Mutation:    Insertion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgfr4 Mutation:  3 strains or lines available
Notes
Mice doubly homozygous for Fgfr3tm1Led and Fgfr4tm1Cxd display a phenotypic similarity to human neonatal bronchopulmonary dysplasia, a major health problem that results from the ventilation of premature infants (J:50677).

References
Original:  J:50677 Weinstein M, et al., FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung. Development. 1998 Sep;125(18):3615-23
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory