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Targeted Allele Detail
Symbol: Fgfr4tm1Cxd
Name: fibroblast growth factor receptor 4; targeted mutation 1, Chu-Xia Deng
MGI ID: MGI:2135678
Synonyms: FR4KO
Gene: Fgfr4  Location: Chr13:55152640-55168759 bp, + strand  Genetic Position: Chr13, 29.8 cM
Germline Transmission:  Earliest citation of germline transmission: J:50677
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsInsertion of a neomycin cassette into exon 6, which encodes the IgII domain. No mRNA was detected in liver from homozygous mutant animals as assayed by Northern blot. Immunohistochemical analysis failed to detect protein in lungs from homozygous mutant mice. (J:50677)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgfr4 Mutation:  19 strains or lines available
Mice doubly homozygous for Fgfr3tm1Led and Fgfr4tm1Cxd display a phenotypic similarity to human neonatal bronchopulmonary dysplasia, a major health problem that results from the ventilation of premature infants (J:50677).
Original:  J:50677 Weinstein M, et al., FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung. Development. 1998 Sep;125(18):3615-23
All:  18 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.10
The Jackson Laboratory