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Targeted Allele Detail
Symbol: Fgfr3tm1Led
Name: fibroblast growth factor receptor 3; targeted mutation 1, Phillip Leder
MGI ID: MGI:2135634
Gene: Fgfr3  Location: Chr5:33721674-33737067 bp, + strand  Genetic Position: Chr5, 17.83 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:32105
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsInsertion of a neomycin cassette into exon 3. Northern blot analysis did not detect mRNA in the brain or the liver of homozygous mutant mice. (J:32105)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgfr3 Mutation:  19 strains or lines available
Mice doubly homozygous for Fgfr3tm1Led and Fgfr4tm1Cxd display a phenotypic similarity to human neonatal bronchopulmonary dysplasia, a major health problem that results from the ventilation of premature infants (J:50677).
Original:  J:32105 Deng C, et al., Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell. 1996 Mar 22;84(6):911-21
All:  15 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.09
The Jackson Laboratory