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Fgfr3tm1Led
Targeted Allele Detail
Nomenclature
Symbol: Fgfr3tm1Led
Name: fibroblast growth factor receptor 3; targeted mutation 1, Phillip Leder
MGI ID: MGI:2135634
Gene: Fgfr3  Location: Chr5:33721724-33737067 bp, + strand  Genetic Position: Chr5, 17.83 cM, cytoband B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:32105
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsInsertion of a neomycin cassette into exon 3. Northern blot analysis did not detect mRNA in the brain or the liver of homozygous mutant mice. (J:32105)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgfr3 Mutation:  8 strains or lines available
Notes
Mice doubly homozygous for Fgfr3tm1Led and Fgfr4tm1Cxd display a phenotypic similarity to human neonatal bronchopulmonary dysplasia, a major health problem that results from the ventilation of premature infants (J:50677).

References
Original:  J:32105 Deng C, et al., Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell. 1996 Mar 22;84(6):911-21
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory