Pdgfra^tm4Sor
Targeted Allele Detail

Summary

• Symbol: Pdgfra^tm4Sor
• Name: platelet derived growth factor receptor, alpha polypeptide; targeted mutation 4, Philippe Soriano
• MGI ID: MGI:2135542
• Synonyms: alphaKI
• Gene: Pdgfra Location: Chr5:75312953-75358876 bp, + strand Genetic Position: Chr5, 39.55 cM
• Alliance: Pdgfra^tm4Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67735
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, No functional change)
• Mutation: Insertion
• Mutation details: A cDNA encoding PDGFalphaR was targeted into the Pdgfra locus. This allele serves as a control for Pdgfra^tm3Sor. Western blot analysis indicated that expression of the targeted Pdgfr locus was disrupted and the introduced receptor was expressed. (J:67735)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdgfra Mutation: 88 strains or lines available

References

• Original: J:67735 Klinghoffer RA, et al., The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions. Mol Cell. 2001 Feb;7(2):343-54
• All: 1 reference(s)