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Targeted Allele Detail
Symbol: Slc12a2tm1Ges
Name: solute carrier family 12, member 2; targeted mutation 1, Gary E Shull
MGI ID: MGI:1935144
Synonyms: Nkcc1-
Gene: Slc12a2  Location: Chr18:58011750-58079893 bp, + strand  Genetic Position: Chr18, 32.15 cM
Slc12a2tm1Ges/Slc12a2tm1Ges mice exhibit growth retardation

Show the 6 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:57651
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsInsertion of a neomycin gene into exon 6. Northern blot analysis of brain, heart, skeletal muscle, lung, kidney, stomach, small intestine and colon failed to detect any mRNA in homozygous mutants. (J:57651)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 155937 assay results
In Structures Affected by this Mutation: 16 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc12a2 Mutation:  34 strains or lines available
Original:  J:57651 Flagella M, et al., Mice lacking the basolateral Na-K-2Cl cotransporter have impaired epithelial chloride secretion and are profoundly deaf. J Biol Chem. 1999 Sep 17;274(38):26946-55
All:  33 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory