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Spontaneous Allele Detail
Symbol: Fbn2fp
Name: fibrillin 2; fused phalanges
MGI ID: MGI:1935123
Synonyms: fp, syfp
Gene: Fbn2  Location: Chr18:58008623-58210487 bp, - strand  Genetic Position: Chr18, 32.15 cM, cytoband D-E1
Limb clasping, reduced grip strength, and syndactyly in Fbn2mz/Fbn2mz, Fbn2fp/Fbn2fp and Fbn2mz/Fbn2fp mice

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  C3HeB/FeHu
Allele Type:    Spontaneous
Mutation:    Intragenic deletion
Mutation detailsThis mutation consists of a single nucleotide deletion in exon 39 in the Fbn2 gene, causing a frameshift of 44 amino acids before the introduction of a stop codon. RT-PCR analysis revealed that less Fbn2 transcript is produced in the fused phalanges mouse than in the parental strain from which it arose. (J:68881)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 12 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fbn2 Mutation:  5 strains or lines available
Original:  J:13514 Hummel KP, et al., Fused phalanges. Mouse News Lett. 1971;45:28
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory