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Egfrtm1Rdk
Targeted Allele Detail
Nomenclature
Symbol: Egfrtm1Rdk
Name: epidermal growth factor receptor; targeted mutation 1, Rik Derynck
MGI ID: MGI:1935113
Synonyms: EGF-R -
Gene: Egfr  Location: Chr11:16752203-16913907 bp, + strand  Genetic Position: Chr11, 9.41 cM, cytoband A1-A4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:27464
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin selection cassette was inserted into exon 2, which encodes the amino terminal segment of the protein. (J:27464)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 29 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Egfr Mutation:  14 strains or lines available
References
Original:  J:27464 Miettinen PJ, et al., Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature. 1995 Jul 27;376(6538):337-41
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory