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Targeted Allele Detail
Symbol: Dag1tm1Kcam
Name: dystroglycan 1; targeted mutation 1, Kevin P Campbell
MGI ID: MGI:1934902
Synonyms: Dag1neo2, DG-
Gene: Dag1  Location: Chr9:108204634-108263958 bp, - strand  Genetic Position: Chr9, 59.08 cM
Germline Transmission:  Earliest citation of germline transmission: J:40601
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance gene replaced part of exon 2, including the splice acceptor site and a large part of the coding sequence. No detectable transcript was produced from this allele in homozygous embryos (data not shown) and immunohistochemistry experiments on homozygous embryos confirmed that no detectable encoded protein was present. (J:40601)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dag1 Mutation:  84 strains or lines available
Original:  J:40601 Williamson RA, et al., Dystroglycan is essential for early embryonic development: disruption of Reichert's membrane in Dag1-null mice. Hum Mol Genet. 1997 Jun;6(6):831-41
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.04
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