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Lamc1tm1Edg
Targeted Allele Detail
Nomenclature
Symbol: Lamc1tm1Edg
Name: laminin, gamma 1; targeted mutation 1, David Edgar
MGI ID: MGI:1934900
Gene: Lamc1  Location: Chr1:153218922-153332786 bp, - strand  Genetic Position: Chr1, 65.3 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:52418
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsAn IRES-betageo gene was inserted into exon 1. Northern blot analysis on doubly targeted ES cells demonstrated that no transcript was expressed from this allele. (J:52418)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lamc1 Mutation:  114 strains or lines available
References
Original:  J:52418 Smyth N, et al., Absence of basement membranes after targeting the LAMC1 gene results in embryonic lethality due to failure of endoderm differentiation. J Cell Biol. 1999 Jan 11;144(1):151-60
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory