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Hspg2tm1Nid
Targeted Allele Detail
Nomenclature
Symbol: Hspg2tm1Nid
Name: perlecan (heparan sulfate proteoglycan 2); targeted mutation 1, National Institute of Dental and Craniofacial Research
MGI ID: MGI:1934891
Synonyms: Hspg2-
Gene: Hspg2  Location: Chr4:137196080-137297941 bp, + strand  Genetic Position: Chr4, 69.93 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67299
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted into exon 7 of the gene, which encodes the N-terminus of the LDL-receptor-like domain of the protein. Northern blots of fibroblast RNA from homozygous mutant mice showed no detectable transcript for the targeted gene. (J:67299)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 15 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hspg2 Mutation:  242 strains or lines available
References
Original:  J:67299 Arikawa-Hirasawa E, et al., Perlecan is essential for cartilage and cephalic development. Nat Genet. 1999 Nov;23(3):354-8
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory