About   Help   FAQ
Hspg2tm1Nid
Targeted Allele Detail
Summary
Symbol: Hspg2tm1Nid
Name: perlecan (heparan sulfate proteoglycan 2); targeted mutation 1, National Institute of Dental and Craniofacial Research
MGI ID: MGI:1934891
Synonyms: Hspg2-
Gene: Hspg2  Location: Chr4:137196080-137297941 bp, + strand  Genetic Position: Chr4, 69.93 cM
Alliance: Hspg2tm1Nid page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67299
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted into exon 7 of the gene, which encodes the N-terminus of the LDL-receptor-like domain of the protein. Northern blots of fibroblast RNA from homozygous mutant mice showed no detectable transcript for the targeted gene. (J:67299)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 15 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hspg2 Mutation:  308 strains or lines available
References
Original:  J:67299 Arikawa-Hirasawa E, et al., Perlecan is essential for cartilage and cephalic development. Nat Genet. 1999 Nov;23(3):354-8
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory