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Fcer2atm1Max
Targeted Allele Detail
Nomenclature
Symbol: Fcer2atm1Max
Name: Fc receptor, IgE, low affinity II, alpha polypeptide; targeted mutation 1, Max-Planck-Institut fur Immunbiologie
MGI ID: MGI:1934672
Synonyms: CD23-, Fc epsilon RII
Gene: Fcer2a  Location: Chr8:3681737-3694175 bp, - strand  Genetic Position: Chr8, 1.92 cM, cytoband A1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:18952
Parent Cell Line:  BL/6-III (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced exons 3 and 4. Northern blot analysis did not detect mRNA in homozygous mutant spleen. Flow cytometric analysis did not detect membrane-bound protein in homozygous mutant spleen. (J:18952)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fcer2a Mutation:  13 strains or lines available
References
Original:  J:18952 Yu P, et al., Negative feedback regulation of IgE synthesis by murine CD23. Nature. 1994 Jun 30;369(6483):753-6
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory