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Trp63tm2Brd
Targeted Allele Detail
Nomenclature
Symbol: Trp63tm2Brd
Name: transformation related protein 63; targeted mutation 2, Allan Bradley
MGI ID: MGI:1934580
Synonyms: p63Brdm2, p63KO
Gene: Trp63  Location: Chr16:25683763-25892102 bp, + strand  Genetic Position: Chr16, 17.37 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:54636
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsAn integration vector disrupts the reading frame within exon 10. Northern blot analysis on homozygous mutant animals indicates that an mRNA transcript is not produced from this allele. (J:54636)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 9 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trp63 Mutation:  13 strains or lines available
References
Original:  J:54636 Mills AA, et al., p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature. 1999 Apr 22;398(6729):708-13
All:  37 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory