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Targeted Allele Detail
Symbol: Cxcr4tm1Tng
Name: chemokine (C-X-C motif) receptor 4; targeted mutation 1, Takashi Nagasawa
MGI ID: MGI:1934442
Synonyms: CXCR4-
Gene: Cxcr4  Location: Chr1:128588199-128592293 bp, - strand  Genetic Position: Chr1, 56.43 cM
Germline Transmission:  Earliest citation of germline transmission: J:69256
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced most of exon 2 including all of the sequences encoding the transmembrane regions. RT-PCR of E18.5 embryos did not detect transcript in liver tissue from homozygous animals. (J:69256)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 7 assay results
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cxcr4 Mutation:  10 strains or lines available
Original:  J:69256 Tachibana K, et al., The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature. 1998 Jun 11;393(6685):591-4
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory