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Cxcr4tm1Tng
Targeted Allele Detail
Nomenclature
Symbol: Cxcr4tm1Tng
Name: chemokine (C-X-C motif) receptor 4; targeted mutation 1, Takashi Nagasawa
MGI ID: MGI:1934442
Synonyms: CXCR4-
Gene: Cxcr4  Location: Chr1:128588199-128592293 bp, - strand  Genetic Position: Chr1, 56.43 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:69256
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced most of exon 2 including all of the sequences encoding the transmembrane regions. RT-PCR of E18.5 embryos did not detect transcript in liver tissue from homozygous animals. (J:69256)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cxcr4 Mutation:  19 strains or lines available
References
Original:  J:69256 Tachibana K, et al., The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature. 1998 Jun 11;393(6685):591-4
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory