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Targeted Allele Detail
Symbol: Cxcl12tm1Tng
Name: chemokine (C-X-C motif) ligand 12; targeted mutation 1, Takashi Nagasawa
MGI ID: MGI:1934384
Synonyms: PBSF/SDF-1-, SDF-1-
Gene: Cxcl12  Location: Chr6:117145496-117158328 bp, + strand  Genetic Position: Chr6, 54.81 cM, cytoband F1
Cerebellum defects in Cxcr4tm1Qma/Cxcr4tm1Qma and Cxcl12tm1Tng/Cxcl12tm1Tng mice.

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:34750
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsReplacement of exon 2 and flanking intronic sequences with a neomycin cassette. RT-PCR studies using primers that bracket exon 2 did not detect transcript in homozygous mutant E16.5 embryos. (J:34750)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 30 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cxcl12 Mutation:  21 strains or lines available
Original:  J:34750 Nagasawa T, et al., Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature. 1996 Aug 15;382(6592):635-8
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.21
The Jackson Laboratory