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Targeted Allele Detail
Symbol: Pax6tm1Pgr
Name: paired box 6; targeted mutation 1, Peter Gruss
MGI ID: MGI:1934347
Synonyms: Pax6lacZ, Pax6-lacZ, Pax6::lacZ
Gene: Pax6  Location: Chr2:105668900-105697364 bp, + strand  Genetic Position: Chr2, 55.31 cM
Germline Transmission:  Earliest citation of germline transmission: J:40439
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe start codon in exon 4 and the entire paired domain of Pax6 was replaced with a beta-galactosidase gene followed by a neomycin cassette. Beta-galactosidase was expressed in embryos in a pattern identical to Pax6. (J:40439)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 100 assay results
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Pax6 Mutation:  43 strains or lines available
Original:  J:40439 St-Onge L, et al., Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas. Nature. 1997 May 22;387(6631):406-9
All:  40 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory