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Targeted Allele Detail
Symbol: Soat1tm1Ishi
Name: sterol O-acyltransferase 1; targeted mutation 1, Shun Ishibashi
MGI ID: MGI:1934032
Synonyms: ACAT-1
Gene: Soat1  Location: Chr1:156424525-156474331 bp, - strand  Genetic Position: Chr1, 67.71 cM
Narrow eye fissures and atrophic meibomian glands in Soat1tm1Ishi/Soat1tm1Ishi mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:63468
Parent Cell Line:  JH1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced 4 kb of sequence encoding the first transmembrane domain and a conserved serine. Northern blot analyses of homozygous mutant mice did not detect any transcripts in macrophages, adrenal glands, ovaries and testes. Western blot analyses of macrophages, adrenal glands, ovaries, and testes did not detect the protein in homozygous mutant mice. (J:63468)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Soat1 Mutation:  11 strains or lines available
Original:  J:63468 Yagyu H, et al., Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia. J Biol Chem. 2000 Jul 14;275(28):21324-30
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory