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Targeted Allele Detail
Symbol: Prltm1Hmn
Name: prolactin; targeted mutation 1, Nelson D Horseman
MGI ID: MGI:1934021
Synonyms: PRL-
Gene: Prl  Location: Chr13:27057577-27065191 bp, + strand  Genetic Position: Chr13, 12.25 cM
Germline Transmission:  Earliest citation of germline transmission: J:45243
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA PGK neomycin cassette was inserted into exon 4. This sequence encodes the second alpha helix of the protein. RT-PCR analysis confirmed a lack of wild-type transcript in homozygous mutant mice. Western blotting of pituitary gland extracts revealed the presence of a unique immunoreactive ~10-kDa truncated protein product in homozygous mutant mice. Disrupted prolactin synthesis was confirmed by biological assays. (J:45243)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Prl Mutation:  15 strains or lines available
Original:  J:45243 Horseman ND, et al., Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene. EMBO J. 1997 Dec 1;16(23):6926-35
All:  23 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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