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Il15ratm1Ama
Targeted Allele Detail
Nomenclature
Symbol: Il15ratm1Ama
Name: interleukin 15 receptor, alpha chain; targeted mutation 1, Averil Ma
MGI ID: MGI:1934016
Synonyms: Il-15R-, Il15ra-, IL-15Ralpha-, IL-15Ralpha-, RalphaKO
Gene: Il15ra  Location: Chr2:11705290-11734317 bp, + strand  Genetic Position: Chr2, 8.97 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:51337
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment containing exons 2 and 3 was replaced by a neomycin resistance cassette. These sequences encode the ligand binding and proline/threonine rich extracellular domains. Northern blot analysis demonstrated that the transcript was not detectable in liver RNA from homozygous mice. (J:51337)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il15ra Mutation:  21 strains or lines available
References
Original:  J:51337 Lodolce JP, et al., IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity. 1998 Nov;9(5):669-76
All:  57 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/16/2017
MGI 6.09
The Jackson Laboratory