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Hfetm1Gfn
Targeted Allele Detail
Nomenclature
Symbol: Hfetm1Gfn
Name: homeostatic iron regulator; targeted mutation 1, Susan Gilfillan
MGI ID: MGI:1934013
Synonyms: Hfe0
Gene: Hfe  Location: Chr13:23886017-23894837 bp, - strand  Genetic Position: Chr13, 9.88 cM, cytoband A2-A4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:68025
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation details2.5 kb of sequence containing the second and third exons, which encode the alpha1 and alpha2 putative ligand binding domains, were replaced with a floxed PGK neomycin selection cassette. Northern blots prepared with total RNA isolated from kidney and liver tissue did not detect full length mRNA in homozygous mutant mice. (J:68025)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hfe Mutation:  21 strains or lines available
References
Original:  J:68025 Bahram S, et al., Experimental hemochromatosis due to MHC class I HFE deficiency: immune status and iron metabolism. Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13312-7
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory