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Cd14tm1Frm
Targeted Allele Detail
Nomenclature
Symbol: Cd14tm1Frm
Name: CD14 antigen; targeted mutation 1, Mason W Freeman
MGI ID: MGI:1934009
Synonyms: CD14-
Gene: Cd14  Location: Chr18:36725067-36726798 bp, - strand  Genetic Position: Chr18, 19.46 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65107
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a genomic fragment containing the entire coding sequences of the gene. Western blot analysis confirmed an absence of CD14 protein in macrophage lysates derived from homozygous mice. (J:65107)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cd14 Mutation:  18 strains or lines available
References
Original:  J:65107 Moore KJ, et al., Divergent response to LPS and bacteria in CD14-deficient murine macrophages. J Immunol. 2000 Oct 15;165(8):4272-80
All:  92 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory