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Targeted Allele Detail
Symbol: Ntrk2tm2Kln
Name: neurotrophic tyrosine kinase, receptor, type 2; targeted mutation 2, Rudiger Klein
MGI ID: MGI:1933974
Synonyms: trkBlox, Trkblx
Gene: Ntrk2  Location: Chr13:58806569-59133970 bp, + strand  Genetic Position: Chr13, 31.2 cM
Germline Transmission:  Earliest citation of germline transmission: J:58229
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsInsertion of loxP sites flanking exon K2, encoding sequences in the kinase domain of the protein. An adjacent frt-flanked neomycin cassette was removed by crossing to transgenic mice expressing the Flp recombinase. This mutation had no effect on the normal function of the gene. (J:58229)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ntrk2 Mutation:  15 strains or lines available
Original:  J:58229 Minichiello L, et al., Essential role for TrkB receptors in hippocampus-mediated learning. Neuron. 1999 Oct;24(2):401-14
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory