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Ntrk1tm1Par
Targeted Allele Detail
Nomenclature
Symbol: Ntrk1tm1Par
Name: neurotrophic tyrosine kinase, receptor, type 1; targeted mutation 1, Luis F Parada
MGI ID: MGI:1933963
Synonyms: TrkA-
Gene: Ntrk1  Location: Chr3:87778244-87795162 bp, - strand  Genetic Position: Chr3, 38.62 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60927
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neomycin resistance cassette replaced all coding sequences except the first 53 nucleotides of the exon that contains the translation initiation codon. (J:60927)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ntrk1 Mutation:  35 strains or lines available
References
Original:  J:60927 Liebl DJ, et al., Loss of brain-derived neurotrophic factor-dependent neural crest-derived sensory neurons in neurotrophin-4 mutant mice. Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2297-302
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/11/2018
MGI 6.12
The Jackson Laboratory