Ntf3^tm1Lfr
Targeted Allele Detail

Summary

• Symbol: Ntf3^tm1Lfr
• Name: neurotrophin 3; targeted mutation 1, Louis F Reichardt
• MGI ID: MGI:1933843
• Synonyms: NT-3 (-), NT3-lacZ, NT3:lacZ, NT-3^lacZneo, Ntf3^lacZ
• Gene: Ntf3 Location: Chr6:126078375-126143703 bp, - strand Genetic Position: Chr6, 60.45 cM
• Alliance: Ntf3^tm1Lfr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:18984
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Insertion of a lacZ-neomycin resistance cassette replaced the single coding exon beginning at the first methionine codon. (J:18984)

Expression

In Mice Carrying this Mutation:	340 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ntf3 Mutation: 24 strains or lines available

References

• Original: J:18984 Farinas I, et al., Severe sensory and sympathetic deficits in mice lacking neurotrophin-3. Nature. 1994 Jun 23;369(6482):658-61
• All: 33 reference(s)