Notch1^tm1Agt
Targeted Allele Detail

Summary

• Symbol: Notch1^tm1Agt
• Name: notch 1; targeted mutation 1, Michael Aguet
• MGI ID: MGI:1933835
• Synonyms: floxNotch1, N1^flox, Notch1^F, Notch1^flox, Notch1^lox
• Gene: Notch1 Location: Chr2:26347914-26393834 bp, - strand Genetic Position: Chr2, 18.91 cM
• Alliance: Notch1^tm1Agt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55400
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Insertion of loxP sites flanking the first coding exon of the gene. This mutation had no effect on the normal function of the gene. An adjacent loxP flanked neomycin cassette was removed by Cre-mediated recombination in ES cells prior to production of chimeric animals. (J:55400)

Expression

In Mice Carrying this Mutation:	33 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Notch1^tm1Agt

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Notch1 Mutation: 115 strains or lines available

References

• Original: J:55400 Radtke F, et al., Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity. 1999 May;10(5):547-58
• All: 122 reference(s)