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Targeted Allele Detail
Symbol: Notch1tm1Agt
Name: notch 1; targeted mutation 1, Michael Aguet
MGI ID: MGI:1933835
Synonyms: floxNotch1, N1flox, Notch1F, Notch1flox, Notch1lox
Gene: Notch1  Location: Chr2:26457902-26503822 bp, - strand  Genetic Position: Chr2, 18.91 cM
Germline Transmission:  Earliest citation of germline transmission: J:55400
Parent Cell Line:  GS1 (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsInsertion of loxP sites flanking the first coding exon of the gene. This mutation had no effect on the normal function of the gene. An adjacent loxP flanked neomycin cassette was removed by Cre-mediated recombination in ES cells prior to production of chimeric animals. (J:55400)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 5 assay results
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Notch1 Mutation:  32 strains or lines available
Original:  J:55400 Radtke F, et al., Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity. 1999 May;10(5):547-58
All:  105 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory