Cdkn2c^tm1Yxi
Targeted Allele Detail

Summary

• Symbol: Cdkn2c^tm1Yxi
• Name: cyclin dependent kinase inhibitor 2C; targeted mutation 1, Yue Xiong
• MGI ID: MGI:1933762
• Synonyms: p18^-, p18^INK4c-, p18/INK4c^-
• Gene: Cdkn2c Location: Chr4:109518073-109523953 bp, - strand Genetic Position: Chr4, 51.32 cM
• Alliance: Cdkn2c^tm1Yxi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50053
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 2kb of sequence containing exon 3, which encodes amino acids 42- 168. No protein was detected in Western blots of immunoprecipitates from lysates derived from heart, kidney, lung, skeletal muscle or spleen of homozygous mutant mice. (J:50053)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cdkn2c^tm1Yxi

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdkn2c Mutation: 16 strains or lines available

References

• Original: J:50053 Franklin DS, et al., CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis. Genes Dev. 1998 Sep 15;12(18):2899-911
• All: 31 reference(s)