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Cdkn2ctm1Yxi
Targeted Allele Detail
Nomenclature
Symbol: Cdkn2ctm1Yxi
Name: cyclin dependent kinase inhibitor 2C; targeted mutation 1, Yue Xiong
MGI ID: MGI:1933762
Synonyms: p18-, p18INK4c-, p18/INK4c-
Gene: Cdkn2c  Location: Chr4:109660876-109666756 bp, - strand  Genetic Position: Chr4, 51.32 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:50053
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced 2kb of sequence containing exon 3, which encodes amino acids 42- 168. No protein was detected in Western blots of immunoprecipitates from lysates derived from heart, kidney, lung, skeletal muscle or spleen of homozygous mutant mice. (J:50053)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdkn2c Mutation:  10 strains or lines available
References
Original:  J:50053 Franklin DS, et al., CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis. Genes Dev. 1998 Sep 15;12(18):2899-911
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory