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Cdkn1ctm1Bbd
Targeted Allele Detail
Nomenclature
Symbol: Cdkn1ctm1Bbd
Name: cyclin-dependent kinase inhibitor 1C (P57); targeted mutation 1, Mariano Barbacid
MGI ID: MGI:1933757
Synonyms: p57kip2 (-)
Gene: Cdkn1c  Location: Chr7:143458339-143461050 bp, - strand  Genetic Position: Chr7, 88.22 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:40142
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsDeletion of 1.1 kb of genomic sequence that includes the first exon and half the second exon, encoding amino acid residues 1-181 of the protein. No protein was detected in Western blots of lysates of primary embryo fibroblasts derived from homozygous mutant mice. (J:40142)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdkn1c Mutation:  10 strains or lines available
References
Original:  J:40142 Yan Y, et al., Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development. Genes Dev. 1997 Apr 15;11(8):973-83
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory