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Targeted Allele Detail
Symbol: Pdgfbtm1Cbet
Name: platelet derived growth factor, B polypeptide; targeted mutation 1, Christer Betsholtz
MGI ID: MGI:1933334
Synonyms: PDGF-B-
Gene: Pdgfb  Location: Chr15:79995900-80014808 bp, - strand  Genetic Position: Chr15, 37.85 cM, cytoband E
Abnormal endothelial cell morphology and increased caveolae formation in Pdgfbtm1Cbet/Pdgfbtm1Cbet brains

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:20017
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neomycin cassette replaced part of exon 3 and all of exon 4. The targeting event is predicted to prevent the formation of a major part of the protein, including cysteine residues involved in all inter- and intramolecular sulfide bridges. (J:20017)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 42 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdgfb Mutation:  7 strains or lines available
Mutants in J:89186 provide a model for microvascular changes that bear striking resemblance to diabetic microangiopathy.
Original:  J:20017 Leveen P, et al., Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities. Genes Dev. 1994 Aug 15;8(16):1875-87
All:  20 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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