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Targeted Allele Detail
Symbol: Tob1tm1Tya
Name: transducer of ErbB-2.1; targeted mutation 1, Tadashi Yamamoto
MGI ID: MGI:1933294
Synonyms: tob-
Gene: Tob1  Location: Chr11:94102280-94106321 bp, + strand  Genetic Position: Chr11, 58.9 cM, cytoband C
Germline Transmission:  Earliest citation of germline transmission: J:66504
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA PGK-neomycin resistance cassette was inserted into the only exon of the gene. Western blot analysis of primary embryonic fibroblasts detected only one of the two wild-type forms of the protein in homozygous mutant mice. Northern blot analysis did not detect transcript in osteoblast lineage cells derived from calvariae of homozygous mutant newborns. Also, BMP2-stimulated DNA synthesis was enhanced in these cells compared to wild-type. (J:66504)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Tob1 Mutation:  22 strains or lines available
Original:  J:66504 Yoshida Y, et al., Negative regulation of BMP/Smad signaling by Tob in osteoblasts. Cell. 2000 Dec 22;103(7):1085-97
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory