About   Help   FAQ
Tob1tm1Tya
Targeted Allele Detail
Nomenclature
Symbol: Tob1tm1Tya
Name: transducer of ErbB-2.1; targeted mutation 1, Tadashi Yamamoto
MGI ID: MGI:1933294
Synonyms: tob-
Gene: Tob1  Location: Chr11:94211454-94215495 bp, + strand  Genetic Position: Chr11, 58.9 cM, cytoband C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66504
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA PGK-neomycin resistance cassette was inserted into the only exon of the gene. Western blot analysis of primary embryonic fibroblasts detected only one of the two wild-type forms of the protein in homozygous mutant mice. Northern blot analysis did not detect transcript in osteoblast lineage cells derived from calvariae of homozygous mutant newborns. Also, BMP2-stimulated DNA synthesis was enhanced in these cells compared to wild-type. (J:66504)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Tob1 Mutation:  18 strains or lines available
References
Original:  J:66504 Yoshida Y, et al., Negative regulation of BMP/Smad signaling by Tob in osteoblasts. Cell. 2000 Dec 22;103(7):1085-97
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/20/2017
MGI 6.10
The Jackson Laboratory