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Alox5tm1Bhk
Targeted Allele Detail
Nomenclature
Symbol: Alox5tm1Bhk
Name: arachidonate 5-lipoxygenase; targeted mutation 1, Beverly Koller
MGI ID: MGI:1933120
Synonyms: 5LO-
Gene: Alox5  Location: Chr6:116410077-116461178 bp, - strand  Genetic Position: Chr6, 53.79 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:68714
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neomycin cassette replaced 1.25 kb of sequence in exons 9 and 10. RT-PCR studies did not detect transcript in stimulated peritoneal macrophages of homozygous mutant mice. (J:68714)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Alox5 Mutation:  27 strains or lines available
References
Original:  J:68714 Goulet JL, et al., Altered inflammatory responses in leukotriene-deficient mice. Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12852-6
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory