Alox5^tm1Bhk
Targeted Allele Detail

Summary

• Symbol: Alox5^tm1Bhk
• Name: arachidonate 5-lipoxygenase; targeted mutation 1, Beverly Koller
• MGI ID: MGI:1933120
• Synonyms: 5LO-
• Gene: Alox5 Location: Chr6:116387038-116438139 bp, - strand Genetic Position: Chr6, 53.79 cM
• Alliance: Alox5^tm1Bhk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68714
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin cassette replaced 1.25 kb of sequence in exons 9 and 10. RT-PCR studies did not detect transcript in stimulated peritoneal macrophages of homozygous mutant mice. (J:68714)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Alox5 Mutation: 45 strains or lines available

References

• Original: J:68714 Goulet JL, et al., Altered inflammatory responses in leukotriene-deficient mice. Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12852-6
• All: 17 reference(s)