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Targeted Allele Detail
Symbol: F9tm1Ver
Name: coagulation factor IX; targeted mutation 1, Inder M Verma
MGI ID: MGI:1932265
Synonyms: FIX (-)
Gene: F9  Location: ChrX:59999464-60030759 bp, + strand  Genetic Position: ChrX, 33.5 cM, cytoband A6-A7
Bleeding disorder of F9tm1Ver/F9tm1Ver mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:43590
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsReplacement of the last exon, encoding a large portion of the catalytic domain, with a neomycin cassette. mRNA was not detected in mutant mouse liver as assayed by Northern blot analysis, and no protein could be detected by Western blot analysis of plasma. (J:43590)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any F9 Mutation:  1 strain or line available
Original:  J:43590 Wang L, et al., A factor IX-deficient mouse model for hemophilia B gene therapy. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11563-6
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
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