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Cdk5r1tm1Lht
Targeted Allele Detail
Nomenclature
Symbol: Cdk5r1tm1Lht
Name: cyclin-dependent kinase 5, regulatory subunit 1 (p35); targeted mutation 1, Li-Huei Tsai
MGI ID: MGI:1931885
Synonyms: p35-
Gene: Cdk5r1  Location: Chr11:80477046-80481179 bp, + strand  Genetic Position: Chr11, 47.94 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:38857
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A neomycin resistance cassette replaced 1.4 kb of sequence, including the entire open reading frame. (J:38857)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 63 assay results
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdk5r1 Mutation:  3 strains or lines available
References
Original:  J:38857 Chae T, et al., Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality. Neuron. 1997 Jan;18(1):29-42
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/12/2019
MGI 6.13
The Jackson Laboratory