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Vimtm2Cba
Targeted Allele Detail
Nomenclature
Symbol: Vimtm2Cba
Name: vimentin; targeted mutation 2, Charles Babinet
MGI ID: MGI:1931879
Synonyms: Vim-, Vim2
Gene: Vim  Location: Chr2:13573927-13582826 bp, + strand  Genetic Position: Chr2, 10.04 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:21588
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 1 of the Vim gene was disrupted by insertion of a neomycin resistance cassette. Northern analysis of homozygous mutant animals did not detect Vim transcript in lung and spleen, but did detect a minor aberrant transcript in heart. Western analysis and immunofluorescence microsopy did not detect VIM protein in tissues of homozygous mutant mice. (J:21588)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vim Mutation:  15 strains or lines available
References
Original:  J:21588 Colucci-Guyon E, et al., Mice lacking vimentin develop and reproduce without an obvious phenotype. Cell. 1994 Nov 18;79(4):679-94
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory