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Targeted Allele Detail
Symbol: Gpr143tm1Inc
Name: G protein-coupled receptor 143; targeted mutation 1, Barbara Incerti
MGI ID: MGI:1931862
Synonyms: Oa1-
Gene: Gpr143  Location: ChrX:152781921-152808646 bp, + strand  Genetic Position: ChrX, 68.46 cM, cytoband F2-F3
Germline Transmission:  Earliest citation of germline transmission: J:66139
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-hprt expression cassette replaced exon 1 including the start codon of the gene. Several human mutations are located in the corresponding human exon 1. Northern analysis of primary melanocyte cultures did not detect transcript in homozygous mutant neonates. (J:66139)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gpr143 Mutation:  5 strains or lines available
Original:  J:66139 Incerti B, et al., Oa1 knock-out: new insights on the pathogenesis of ocular albinism type 1. Hum Mol Genet. 2000 Nov 22;9(19):2781-8
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory