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Targeted Allele Detail
Symbol: Kcnq1tm1Apf
Name: potassium voltage-gated channel, subfamily Q, member 1; targeted mutation 1, Andrew P Feinberg
MGI ID: MGI:1931858
Synonyms: Kvlqt1-
Gene: Kcnq1  Location: Chr7:143106877-143427050 bp, + strand  Genetic Position: Chr7, 88.12 cM
Cochlear abnormalities in Kcnq1tm1Apf/Kcnq1tm1Apf mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:66428
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsInsertion of a neomycin resistance cassette into exon 1 disrupted the gene. The authors predict that all isoforms of the protein would be inactivated in homozygous mutant animals. RT-PCR did not detect expression of the tanscript in tissues of homozygous mice. (J:66428)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 17 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnq1 Mutation:  16 strains or lines available
Original:  J:66428 Lee MP, et al., Targeted disruption of the kvlqt1 gene causes deafness and gastric hyperplasia in mice. J Clin Invest. 2000 Dec;106(12):1447-55
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
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