Ccr1^tm1Gao
Targeted Allele Detail

Summary

• Symbol: Ccr1^tm1Gao
• Name: C-C motif chemokine receptor 1; targeted mutation 1, Ji-Liang Gao
• MGI ID: MGI:1931850
• Synonyms: CCR1-
• Gene: Ccr1 Location: Chr9:123762163-123768729 bp, - strand Genetic Position: Chr9, 75.05 cM, cytoband F
• Alliance: Ccr1^tm1Gao page

Ccr1^tm1Gao/Ccr1^tm1Gao and control mice underwent bile duct ligation or sham operation. Macrophage infiltration was determined by immunohistochemistry for F4/80

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:41324
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced open reading frame sequences that correspond to 33% of the protein, from the third to the fifth transmembrane segment. Transcript was not detected in neutrophils of homozygous mutant animals. (J:41324)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ccr1^tm1Gao

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 9 strains available Cell Lines: 0 lines available
• Carrying any Ccr1 Mutation: 37 strains or lines available

References

• Original: J:41324 Gao JL, et al., Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1. J Exp Med. 1997 Jun 2;185(11):1959-68
• All: 59 reference(s)