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Crkltm1Imo
Targeted Allele Detail
Nomenclature
Symbol: Crkltm1Imo
Name: v-crk avian sarcoma virus CT10 oncogene homolog-like; targeted mutation 1, Akira Imamoto
MGI ID: MGI:1931805
Synonyms: Crkol -
Gene: Crkl  Location: Chr16:17451987-17487434 bp, + strand  Genetic Position: Chr16, 10.82 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67826
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA loxP flanked neo cassette was inserted in the first coding exon. Western blot analysis confirmed that no protein was expressed in homozygous mutant embryos. (J:67826)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 15 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Crkl Mutation:  5 strains or lines available
References
Original:  J:67826 Guris DL, et al., Mice lacking the homologue of the human 22q11.2 gene CRKL phenocopy neurocristopathies of DiGeorge syndrome. Nat Genet. 2001 Mar;27(3):293-8
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory