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Itgamtm1Myd
Targeted Allele Detail
Nomenclature
Symbol: Itgamtm1Myd
Name: integrin alpha M; targeted mutation 1, Tanya N Mayadas
MGI ID: MGI:1931533
Synonyms: Cd11b-, CD11b/CD18 deficiency, CD11b KO, CR3-, Itgamtm1Tmn, Mac-1-
Gene: Itgam  Location: Chr7:128062640-128118491 bp, + strand  Genetic Position: Chr7, 69.93 cM, cytoband F4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:38052
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsReplacement of the exon encoding the translational initiation codon and 15 amino acids of the signal peptide with a neomycin cassette. (J:38052)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itgam Mutation:  2 strains or lines available
References
Original:  J:38052 Coxon A, et al., A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity. 1996 Dec;5(6):653-66
All:  114 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory