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Sftpdtm1Jhf
Targeted Allele Detail
Nomenclature
Symbol: Sftpdtm1Jhf
Name: surfactant associated protein D; targeted mutation 1, James H Fisher
MGI ID: MGI:1931530
Synonyms: Sftpd-, SP-D(-)
Gene: Sftpd  Location: Chr14:41172214-41185149 bp, - strand  Genetic Position: Chr14, 22.36 cM
Progressive enlargement of alveolar macrophages from Sftpdtm1Jhf/Sftpdtm1Jhf mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:50436
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Exon 2 was replaced with a neomycin cassette. (J:50436)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sftpd Mutation:  4 strains or lines available
References
Original:  J:50436 Korfhagen TR, et al., Surfactant protein-D regulates surfactant phospholipid homeostasis in vivo. J Biol Chem. 1998 Oct 23;273(43):28438-43
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/10/2019
MGI 6.14
The Jackson Laboratory