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H2-D1tm1Bpe
Targeted Allele Detail
Nomenclature
Symbol: H2-D1tm1Bpe
Name: histocompatibility 2, D region locus 1; targeted mutation 1, Beatrice Perarnau
MGI ID: MGI:1931445
Synonyms: D-, Db-, H-2Db-, H-2Db knockout, H-2 Dbo, H-2Do, HHD
Gene: H2-D1  Location: Chr17:35482070-35486473 bp, + strand  Genetic Position: Chr17, 18.61 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:41077
Parent Cell Line:  CGR8 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1, 2 and 3 of the b haplotype gene were replaced with plasmid sequences and a neomycin cassette. (J:41077)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 45 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 9 strains available      Cell Lines: 0 lines available
Carrying any H2-D1 Mutation:  37 strains or lines available
References
Original:  J:41077 Pascolo S, et al., HLA-A2.1-restricted education and cytolytic activity of CD8(+) T lymphocytes from beta2 microglobulin (beta2m) HLA-A2.1 monochain transgenic H-2Db beta2m double knockout mice. J Exp Med. 1997 Jun 16;185(12):2043-51
All:  147 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory