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H2-K1tm1Bpe
Targeted Allele Detail
Nomenclature
Symbol: H2-K1tm1Bpe
Name: histocompatibility 2, K1, K region; targeted mutation 1, Beatrice Perarnau
MGI ID: MGI:1931444
Synonyms: H2-Kb-, H-2Ko, K-, Kb-
Gene: H2-K1  Location: Chr17:34214991-34219321 bp, - strand  Genetic Position: Chr17, 17.98 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:54709
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe central part of the H2-K gene, including the second and third exons was replaced by a HPRT minigene. (J:41077, J:54709)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 45 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 9 strains available      Cell Lines: 0 lines available
Carrying any H2-K1 Mutation:  52 strains or lines available
References
Original:  J:54709 Perarnau B, et al., Single H2Kb, H2Db and double H2KbDb knockout mice: peripheral CD8+ T cell repertoire and anti-lymphocytic choriomeningitis virus cytolytic responses. Eur J Immunol. 1999 Apr;29(4):1243-52
All:  135 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory