Il6st^tm1Wme
Targeted Allele Detail

Summary

• Symbol: Il6st^tm1Wme
• Name: interleukin 6 signal transducer; targeted mutation 1, Werner Mueller
• MGI ID: MGI:1931239
• Synonyms: gp130^flox
• Gene: Il6st Location: Chr13:112600604-112643394 bp, + strand Genetic Position: Chr13, 63.73 cM
• Alliance: Il6st^tm1Wme page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67677
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Insertion of loxP sites flanking exon 16. A lox-P flanked neomycin cassette in intron 16 was removed via Cre-mediated recombination in the final allele. (J:67677)

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Il6st Mutation: 80 strains or lines available

References

• Original: J:67677 Betz UA, et al., Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects. J Exp Med. 1998 Nov 16;188(10):1955-65
• All: 78 reference(s)