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Targeted Allele Detail
Symbol: Brca1tm2Cxd
Name: breast cancer 1; targeted mutation 2, Chu-Xia Deng
MGI ID: MGI:1931238
Synonyms: Brca1Co, Brca1F11, Brca1flox, Brca1lox
Gene: Brca1  Location: Chr11:101488764-101551955 bp, - strand  Genetic Position: Chr11, 65.18 cM, cytoband D
Germline Transmission:  Earliest citation of germline transmission: J:54533
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsInsertion of lox-P sites flanking exon 11. A lox-P flanked neomycin cassette in intron 10 was removed by transient Cre expression in ES cells in this allele. Insertions have no effect on normal gene function. (J:54533)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Brca1 Mutation:  41 strains or lines available
Original:  J:54533 Xu X, et al., Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation [see comments]. Nat Genet. 1999 May;22(1):37-43
All:  39 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory