About   Help   FAQ
Brca1tm2Cxd
Targeted Allele Detail
Summary
Symbol: Brca1tm2Cxd
Name: breast cancer 1, early onset; targeted mutation 2, Chu-Xia Deng
MGI ID: MGI:1931238
Synonyms: Brca1Co, Brca1F11, Brca1flox, Brca1lox
Gene: Brca1  Location: Chr11:101379590-101442781 bp, - strand  Genetic Position: Chr11, 65.18 cM, cytoband D
Alliance: Brca1tm2Cxd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:54533
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsInsertion of lox-P sites flanking exon 11. A lox-P flanked neomycin cassette in intron 10 was removed by transient Cre expression in ES cells in this allele. Insertions have no effect on normal gene function. (J:54533)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Mice Carrying this Mutation: 1 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 10 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Brca1tm2Cxd
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Brca1 Mutation:  113 strains or lines available
References
Original:  J:54533 Xu X, et al., Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation [see comments]. Nat Genet. 1999 May;22(1):37-43
All:  74 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory