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Targeted Allele Detail
Symbol: Fgf3tm1Mrc
Name: fibroblast growth factor 3; targeted mutation 1, Mario R Capecchi
MGI ID: MGI:1931059
Synonyms: Fgf3neo, int-2-, int-2neo
Gene: Fgf3  Location: Chr7:144838083-144844436 bp, + strand  Genetic Position: Chr7, 88.85 cM
Germline Transmission:  Earliest citation of germline transmission: J:4501
Parent Cell Line:  CC1.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsAn MC1-neomycin resistance cassette was inserted into the first coding exon, exon 1b, at a site several codons downstream from the signal peptide-coding sequence. (J:28595)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 82 assay results
In Structures Affected by this Mutation: 20 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgf3 Mutation:  14 strains or lines available
Original:  J:4501 Mansour SL, et al., Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear. Development. 1993 Jan;117(1):13-28
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.13
The Jackson Laboratory