Egr2^tm2(cre)Pch
Targeted Allele Detail

Summary

• Symbol: Egr2^tm2(cre)Pch
• Name: early growth response 2; targeted mutation 2, Patrick Charnay
• MGI ID: MGI:1931056
• Synonyms: Egr2::Cre, KCN, Krox-20^Cre, Krox-20-Cre, Krox20/Cre
• Gene: Egr2 Location: Chr10:67371305-67378018 bp, + strand Genetic Position: Chr10, 34.96 cM, cytoband B5
• Alliance: Egr2^tm2(cre)Pch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60874
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Egr2^tm2(cre)Pch expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Egr2 (MGI:95296)

• Mutation details: DNA sequences corresponding to the two alternative initiation codons were replaced by an nls-Cre gene, followed by a neomycin cassette. Expression was expected in the hindbrain, bones and the peripheral nervous system as well as both the male and female germlines. (J:60874)
• Inheritance: Recessive

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Egr2 (mouse) Summary of all recombinase alleles driven by Egr2. Comparative matrix view of recombinase activities Alliance mouse Egr2 gene page

Expression

In Mice Carrying this Mutation:

30 assay results 3 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Egr2^tm2(cre)Pch

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Egr2 Mutation: 31 strains or lines available

References

• Original: J:60874 Voiculescu O, et al., Expression pattern of a Krox-20/Cre knock-in allele in the developing hindbrain, bones, and peripheral nervous system. Genesis. 2000 Feb;26(2):123-6
• All: 86 reference(s)